Hepatitis from dantrolene sodium.

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Hepatitis from dantrolene sodium.

The clinical course and histological changes in the liver during a presumed adverse reaction to the drug dantrolene sodium are described in four patients. After a typical prodrome one developed a moderately severe hepatitis-like illness. Another also had a prodrome but never became jaundiced. In the other two, abnormal liver function tests were detected on routine screening. In each case liver ...

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Dantrolene sodium and management of malignant hyperthermia.

Malignant hyperthermia (MH) is an inherited muscle disorder suffered by patients who undergo a stressful situation or acute trauma or who have been given certain anesthetic agents. 1,2 MH has been called the most common cause of anesthesiarelated death in North America, contributing a large percentage of the 15,000 to 20,000 of such deaths recorded annually.3 The 53% mortality rate of today com...

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A suspected malignant hyperthermia managed without dantrolene sodium

Corresponding author: Bon-Sung Koo, M.D., Department of Anesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170, Jomaru-ro, Wonmi-gu, Bucheon 420-767, Korea. Tel: 82-32-621-5330, Fax: 82-32-621-5322, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non...

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Dantrolene sodium suspension in treatment of spastic cerebral palsy.

A double-blind study was carried out on 20 children with spasticity secondary to cerebral palsy, in order to compare the effects of dantrolene sodium suspension and a placebo. The drug was found to be physiologically active in reducing the force of muscle contraction, but objective functional improvement, as measured by multiple performance tests, was irregular and probably not significant.

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Dantrolene Sodium: A Need of the Day at Tertiary Centre

Malignant hyperthermia (MH) a rare genetic disorder is often associated with congenital disorders which are not diagnosed preoperatively. The incidence of MH being very low is still potentially a fatal disorder in anesthesia practice. Mortality still remains high despite its complex and demanding management. Reporting of MH and MH-like syndrome when treated timely with Dantrolene Sodium drastic...

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ژورنال

عنوان ژورنال: Gut

سال: 1979

ISSN: 0017-5749

DOI: 10.1136/gut.20.1.33